Lexus Enform offers Destination Assist, eDestination, Safety Connect and Lexus Insider.
Destination Assist – Push-button Access to the 24/7 Lexus Response Center
Press the talk button on the steering wheel, wait for the beep:

See the step-by-step process.
Then say “Destination”:

Then the following menu will display a list of options which will be read to you. Say “Call Destination Assist”:

An agent will come on the line to assist you with your destination.
Agent: “Where would you like to go today?”
Driver: I’m going to “Business Name” in “city” and “state”
Agent: “Your destination will be sent to your vehicle, when it appears you’ll select “Go To” and you’ll be directed to your destination”

That’s all there is to it!
If you don’t select “Go To” or “enter” the destination will be saved for you in the computer.

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How can I set up a destination from my computer for my Lexus RX 405H?